RAF Typhoon FGR4s have conducted a mission with French aircraft in a combined operation against an hidden munitions depot in Syria operated by the IS group, per a report from the UK Ministry of Defence.
The site, identified by surveillance, was assessed as containing munitions and bombs, the announcement noted, and was located in mountainous terrain just above the ancient city of Palmyra in central Syria.
"Our fighter planes used precision-guided Paveway IV munitions to strike a series of approach shafts providing entry to the depot... preliminary assessments suggest the objective was successfully hit," the ministry announced.
There was no sign of any civilian impact in the operation late on Saturday and each participating jet made a safe return, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
IS - referred to as the so-called Islamic State - established jihadist rule over large swathes of Syria and Iraq prior to its 2019 collapse.
"This strike underscores the UK's leading role, and commitment to operate in unison with allied nations, to eradicate any re-emergence of Daesh and their dangerous and violent ideologies in the Middle East," UK Defence Secretary the Defence Secretary said.
RAF aircraft have performed patrols over Syria to "prevent any attempted comeback" of the group after its military defeat at the climactic battle in Baghuz in the year 2019, the MoD reported.
"I want to thank all the members of British forces involved in this mission for their skill and their courage," he added. "They were part of a great many UK service members stationed over Christmas and New Year. This mission, to eliminate terrorist threats who threaten our way of life, demonstrates how our armed forces are prepared to act, all year round, ensuring Britain's security domestically and influential overseas."
Last December, the US military executed what it described as a "massive strike" on Daesh sites in Syria, following an attack claimed the lives of two US servicemembers and a civilian linguist in Palmyra.
The United Nations reports Islamic State still boasts an estimated 5,000 to 7,000 fighters in Syria and Iraq.